Griffith came down with the muscular disease Guillain-Barre syndrome in 1983, according to biography.com, but made a full recovery. In 2000, he underwent quadruple bypass surgery, and had hip surgery following a fall in 2007, according to his IMDb profile.
Griffith's first marriage ended in divorce in 1972. He married again in 1976 but divorced after five years, according to biography.com. In 1983, he married Cindi Knight, his current wife.
Griffith is survived by two children from his first marriage, according to the biography site. A third son died of an overdose at the age of 36, according to American Profile.