April 1, 2008 - Claims victory in the presidential election.
May 2, 2008 - The Zimbabwe Electoral Commission announces a runoff election between Tsvangirai and Mugabe, although Tsvangirai receives more votes - 47.9% to 43.2%.
June 22, 2008 - Pulls out of the runoff, declaring that he can "no longer participate in a race that's been marred by the widespread intimidation, torture, mutilation and murder of his supporters."
September 15, 2008 - After successful negotiations, Mugabe and Tsvangirai sign Global Political Agreement which states Tsvangirai will become prime minister and Mugabe will remain president, commander-in-chief and chairman of the cabinet.
January 30, 2009 - The MDC agrees to join the unity government.
February 11, 2009 - Is sworn in as the second Zimbabwean prime minister.
March 6, 2009 - With head and neck injuries, walks away from a head-on collision that kills his wife Susan.
October 16, 2009 - Along with the MDC, Tsvangirai boycotts the coalition government after violence increases and Roy Bennett, one of MDC's leaders, is arrested on charges of terrorism.
November 5, 2009 - Boycott of the coalition government ends.
March 10, 2011 - Says he wants a "divorce" from the 2009 power-sharing agreement after the arrest and harassment of cabinet ministers belonging to the MDC party.
November 30, 2011 - Announces he has divorced his wife, Lorcadia Karimatsenga, of less than two weeks.
April 2012 - Announces engagement to hairdresser Elizabeth Macheka.
September 15, 2012 - Marries Macheka, defying a court order not to. The court said Tsvangirai is already in a 'customary marriage' to another woman. They intend to appeal the cancellation of their marriage license.
November 2012 - Reaches a financial settlement with Lorcadia Karimatsenga to formally end their relationship.
August 3, 2013 - Loses in the presidential election with 34% of the vote, to President Robert Mugabe's 61%, according to the election commission. Tsvangirai alleges widespread fraud and promises to challenge the results in court.