Contador is still serving a ban as a result of his 2010 misdemeanors and will return in August.
The specter of drugs still casts a shadow over cycling and in the build-up to the Tour the United States Anti Doping Agency (USADA) formally charged Armstrong over allegations of doping.
Vaughters, whose team adopt a strict anti-doping stance, is hoping that the increased globalization of the sport and with it the opportunity for more sponsorship revenue to boost its coffers, will play a part in eradicating doping.
"We need all our cyclists to be properly compensated for the incredible physical risks they take every day," said the Garmin-Barracuda boss.
A glimpse at the route for this year's Tour shows just how exacting a test the 21-stage race really is for the 198 starters from 22 teams.
The 3497 kiliometer race will take in 25 categorized climbs in the Alps and Pyrenees, but with 100 km of individual racing against the clock, starting with 6.4 km in the prologue in Liege in Belgium, it favors Wiggins and Evans.
Away from the battle for yellow, Mark Cavendish, who joined Wiggins at the powerful and well-funded Team Sky for 2012, will be defending the maillot vert of the points winner as he bids to add to his fast mounting tally of 20 stage victories in the Tour.
On the nine flat stages, Cavendish and his sprinter colleagues will get their opportunity to cross the line first in the usual hell for leather and often dangerous finishes.
Reigning world champion Cavendish is the leader of that pack and warmed up with three more victories in the Giro.
But given his Olympic aspirations -- the road race at the London Games is just a week after the finish of the Tour -- Simon believes he will not seriously defend his green jersey.
"He will win perhaps three or four stages, but not green," said Simon.
The team principal at Sky Dave Brailsford admits they have split loyalties.
"Our priority this year is the General Classification with Bradley but that doesn't mean we'll neglect the sprint stages, or Mark's bid for green jersey," said Brailsford.
If the main contenders for yellow slip up, Italian Vincenzo Nibali (Liquigas), the 2010 Tour of Spain winner and Belgian Jurgen van den Broeck of Lotto -- a fourth place finisher in 2010 -- are ready to step up.
And what of French chances in their home Tour?
Last year Thomas Voeckler held on to the yellow jersey for nine days, won the admiration of cycling fans everywhere and finished fourth overall behind Evans.
"The biggest hope for us is that another rider can do the same as Voeckler," admitted Simon, who singled out Pierre Rolland, winner of the white jersey last year for best under-25 rider, for a possible high finish.
But all the momentum seems to be with Wiggins, the first genuine British contender for overall victory since Tom Simpson in the 1960s.
Simpson became the first British rider to claim the race leader's yellow jersey in the 1962 and his achievements paved the way for English speaking competitors in a sport entirely dominated by Europeans.
But five years later he died on Mont Ventoux on the 13th stage of the Tour -- the victim of heat exhaustion and a deadly cocktail of drugs and alcohol --- in a doomed and tragic bid for cycling's ultimate prize.
Simpson was a childhood idol for Wiggins and it would appear fitting if he could ride into Paris in three weeks time in yellow and make cycling history.