BOSTON - David Ortiz hit two of Boston's eight homers and also doubled for his 2,000th career hit on Wednesday night to lead the Red Sox to a 20-4 romp over the Detroit Tigers.
Will Middlebrooks hit a grand slam, Ortiz had an RBI double to reach the milestone and Daniel Nava added a two-run homer when Boston pulled away with an eight-run sixth inning.
Ortiz homered again in the five-run seventh -- the 427th of his career to move past Billy Williams and into 47th on baseball's all-time home run list.
AL East-leading Boston has won nine of 11, taking two out of three from the Central-leading Tigers to hold onto the best record in the league. But after scores of 3-0 and 2-1 in the first two games of the series, the Red Sox burst out with a franchise record-tying eight homers and a season-high 20 runs.
Jacoby Ellsbury, Stephen Drew, Mike Napoli and Ryan Lavarnway also homered for the Red Sox.
Ryan Dempster (8-9) allowed four runs on six hits and two walks in six innings, striking out seven to win his second straight start since he was suspended for five games for intentionally hitting New York Yankees slugger Alex Rodriguez.
The Red Sox open a four-game series with the Yankees in New York on Thursday night.
Rick Porcello (11-8) gave up nine runs -- eight of them earned -- on seven hits and four walks in five-plus innings.
Ortiz homered in the fourth to tie the game 4-all, then added an RBI double in the sixth for hit No. 2,000. He waved his batting helmet as he stood on second base while the crowd cheered and home plate umpire Jeff Kellogg helped the Red Sox dugout retrieve the ball.
Ortiz homered the next time up, prompting another standing ovation from the crowd at Fenway Park. The fans remained on their feet until he popped out of the dugout for a curtain call.
Prince Fielder homered for the Tigers, who were without Miguel Cabrera for the third time in four games with a strained abdominal muscle. A reigning triple crown winner, Cabrera leads the majors again with a .355 average with 130 RBIs and is four behind Baltimore's Chris Davis with 43 homers.
Detroit shortstop Jose Iglesias, who was acquired from Boston at the trading deadline, left in the fifth inning with pain in his shins.
Shane Victorino singled with one out in the fifth, stole second and took third when catcher Alex Avila threw the ball into center field. On the 11th pitch of his at-bat, Dustin Pedroia hit a sinking line drive that left fielder Andy Dirks caught just off the grass but he could not keep Victorino from tagging up and scoring to make it 5-4.
The Red Sox blew it open with eight in the sixth thanks to a bases-loaded walk, two homers and Ortiz's double. They added two more in the eighth to make it 20-4.
NOTES: The only other time the Red Sox have hit eight homers in a game was July 4, 1977, against Toronto at Fenway Park. ... Nava has reached base safely in 39 consecutive games, the longest active streak in the majors. ... The Chicago Cubs, run by former Red Sox general manager Theo Epstein, claimed former Red Sox reliever Daniel Bard off waivers. ... Boston manager John Farrell said Clay Buchholz's wife gave birth to a daughter. The right-hander will resume his rehab stint with Triple-A Pawtucket in Rochester on Thursday night before joining the Red Sox in New York. ... Porcello had allowed three or fewer runs in 10 of his last 11 starts. But in his career he is 1-3 with a 10.42 ERA against the Red Sox. ... Victorino went over the short wall along the first-base line to retire Austin Jackson and end the fourth inning. Victorino then returned what appeared to be a cellphone to a woman in the front row.
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