San Francisco receiver Jauan Jennings responded to a cheap shot from Carolina safety Tre'Von Moehrig by throwing a punch after the final whistle.
Quarterback Brock Purdy has been ruled out for his third straight game for the San Francisco 49ers due to a toe injury.
Four-time All-Pro linebacker Fred Warner will need season-ending surgery after he was sidelined by a severe ankle injury during San Francisco's loss to Tampa Bay.
A Lions-Chiefs matchup was considered a potential Super Bowl preview when the schedule came out.
Eddy Piñeiro hit a 41-yard field goal in overtime before San Francisco stopped Kyren Williams on fourth down with 3:36 to play, and the short-handed 49ers hung on for a thrilling 26-23 victory over the Los Angeles Rams.
San Francisco 49ers quarterback Mac Jones was able to return after appearing to hurt his left knee in the third quarter against the Los Angeles Rams.
Quarterback Brock Purdy is highly unlikely to start for the San Francisco 49ers on Sunday because of a toe injury.
Tom Brady plans to play alongside current and former NFL stars in a three-team flag football tournament in Saudi Arabia next year.
San Francisco 49ers quarterback Brock Purdy is a "long shot" to play against the New Orleans Saints on Sunday due to a toe injury.
Christian McCaffrey has been a standout at the San Francisco 49ers' training camp, remaining healthy after missing most of last season because of injuries.
Baker Mayfield got in the middle of a scuffle and injured All-Pro tackle Tristan Wirfs went onto the field on a crutch to join his teammates.
The biggest beneficiary of an extended offseason for the San Francisco 49ers just might have been star running back Christian McCaffrey.
Mac Jones is happy finally to be with coach Kyle Shanahan and the San Francisco 49ers even if it came four years after many expected.
Brock Purdy agreed to a five-year contract extension worth $265 million with the San Francisco 49ers, going from the NFL’s biggest bargain to one of the league’s highest paid players.
George Kittle agreed to a four-year contract extension with the San Francisco 49ers that will make him the highest-paid tight end in NFL history.
Brock Purdy reported to the start of the offseason program for the San Francisco 49ers, while star tight end George Kittle stayed away from the start of the voluntary program.
The Minnesota Vikings acquired restricted free agent running back Jordan Mason from the San Francisco 49ers and rewarded him with a two-year deal worth up to $12 million.
Fullback Kyle Juszczyk is returning to the San Francisco 49ers on a two-year, $8 million contract just days after being cut, according to a person familiar with the deal.
The San Francisco 49ers have given receiver Deebo Samuel permission to seek a trade, according to a person familiar with the situation.
Brock Purdy hurt his surgically repaired throwing elbow late in a loss to the Detroit Lions, the latest blow in an injury-plagued season for the San Francisco 49ers.
The defending NFC champion San Francisco 49ers were eliminated from the playoffs before their game at Miami began on Sunday because of victories by Washington and the Los Angeles Rams.
The San Francisco 49ers have suspended linebacker De’Vondre Campbell for the final three games of the regular season after he refused to enter a game after losing his starting job.
San Francisco coach Kyle Shanahan said linebacker De’Vondre Campbell won’t be part of the 49ers moving forward after he refused to enter a game after losing his starting job.
San Francisco linebacker De’Vondre Campbell refused to enter the game in the third quarter after losing his starting job when Dre Greenlaw returned from an injury.
San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season.
San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.
San Francisco 49ers quarterback Brock Purdy has been limited in practice this week because of a sore throwing shoulder and will likely be a game-time decision for Sunday’s game at Green Bay.
Spending the first half of the season as a spectator while he worked his way back from Achilles tendinitis took its toll on San Francisco 49ers All-Pro running back Christian McCaffrey.
San Francisco 49ers All-Pro running back Christian McCaffrey has looked good in his first week back at practice after being sidelined by Achilles tendinitis and is on track to make his season debut Sunday against Tampa Bay.
San Francisco 49ers rookie receiver Ricky Pearsall will be activated and make his NFL debut against Kansas City 50 days after he was shot in the chest.
Eight months later, the pain of losing a second Super Bowl in five seasons to the Kansas City Chiefs has barely subsided for the San Francisco 49ers as they prepare for a rare regular season rematch.
San Francisco 49ers rookie receiver Ricky Pearsall returned to the field for practice for the first time since he was shot in the chest during an attempted robbery nine days before the season opener.
San Francisco 49ers rookie receiver Ricky Pearsall is set to return to practice next week for the first time since he was shot in the chest in a robbery attempt nine days before the season opener.
San Francisco 49ers All-Pro running back Christian McCaffrey has traveled to Germany to consult with a specialist about his Achilles tendinitis.
Joshua Karty hit a 37-yard field goal with 2 seconds to play, and the Los Angeles Rams staged a spectacular late rally for a 27-24 victory over the San Francisco 49ers.
Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and reserves.
All-Pro running back Christian McCaffrey has been ruled out of this weekend’s game for the San Francisco 49ers because of his lingering calf and Achilles’ injuries.
San Francisco coach Kyle Shanahan said All-Pro running back Christian McCaffrey could have played in the 49ers’ opener if it had been a playoff game but the team held him out to make sure his Achilles tendinitis didn’t become a more serious issue.
San Francisco All-Pro running back Christian McCaffrey is listed as questionable for the season opener against the New York Jets with a sore calf and Achilles.
San Francisco 49ers rookie receiver Ricky Pearsall was at practice as a spectator five days after being shot in the chest during an attempted robbery.
Brandon Aiyuk’s first choice during his lengthy contract dispute with the 49ers that featured social media outbursts, a trade request and an awkward “hold in” was to remain in San Francisco.
San Francisco star receiver Brandon Aiyuk wasn’t at the start of practice despite the team saying he was cleared by doctors to participate.
Brock Purdy was efficient in completing 9 of 12 passes for 96 yards but also threw a red-zone interception as the San Francisco 49ers concluded their preseason with a 24-24 tie Friday night against the Las Vegas Raiders.
The San Francisco 49ers have rewarded All-Pro running back Christian McCaffrey with a contract extension after he won the AP Offensive Player of the Year award in his first full season with the team.
The San Francisco 49ers are planning to cut their longest tenured player by releasing defensive tackle Arik Armstead in a salary cap move.
The San Francisco 49ers have promoted assistant Nick Sorensen to defensive coordinator and hired former Los Angeles Chargers coach Brandon Staley for a role on the team’s staff.
The San Francisco 49ers have fired defensive coordinator Steve Wilks three days after losing the Super Bowl to the Kansas City Chiefs.
San Francisco 49ers coach Kyle Shanahan has heard the criticism that for some reason he is unable to win the big game.
The Kansas City Chiefs are a dynasty and already are looking to become the first team to three-peat in the Super Bowl era.
The Kansas City Chiefs beat the San Francisco 49ers 25-22 in overtime in a Super Bowl unlike any other.
San Francisco's decision to take the ball first in overtime of the Super Bowl will be debated for a while.
Jauan Jennings’ historic Super Bowl milestone will turn into only a footnote after his San Francisco 49ers lost the game.
Nick Bosa has been making a high-profile impact for the San Francisco 49ers on Sundays ever since entering the league as the No. 2 overall pick in 2019.
When the Super Bowl was in the balance in the fourth quarter a year ago, coach Andy Reid’s Kansas City Chiefs put a twist on their frequent pre-snap motion.
Minutes after the San Francisco 49ers finished off a stunning comeback to win the NFC championship, star defender Nick Bosa pulled aside quarterback Brock Purdy and marveled at his journey.
Coach Kyle Shanahan took some convincing before deciding it was worth trading a boatload of draft picks before last season’s trade deadline for Christian McCaffrey.
Steve Wilks has had a roller coaster ride in his first season as defensive coordinator for the San Francisco 49ers.
The San Francisco 49ers made the kind of decision that could set a franchise back for years when they traded three first-round picks to draft Trey Lance third overall in 2021.
A photo of Eminem flipping off 49ers fans in full Detroit Lions gear at the NFC Championship Game is blowing up on social media.
Patrick Mahomes, Travis Kelce and the Kansas City Chiefs are heading to Las Vegas with a chance for a rare repeat while facing the San Francisco 49ers in a Super Bowl rematch from four years ago.
San Francisco 49ers wide receiver Deebo Samuel has been cleared to play in the the NFC championship game against the Detroit Lions after leaving last week’s game with a shoulder injury.
The San Francisco 49ers are back in a familiar spot facing a Detroit Lions team new to this stage.
Quarterback Brock Purdy will sit out the regular-season finale after the San Francisco 49ers have already wrapped up the No. 1 seed in the NFL playoffs.
NFL leading rusher Christian McCaffrey will miss San Francisco’s regular-season finale with a mild calf strain but should be ready to return for the playoffs.
Brock Purdy threw two touchdown passes and the San Francisco 49ers clinched the top seed in the NFC by beating the Washington Commanders 27-10.
If a December matchup between the top two teams in the NFL didn’t provide high enough stakes, the league MVP could be decided Monday night when the San Francisco 49ers host the Baltimore Ravens.
Brock Purdy threw three touchdown passes, including a 66-yarder to George Kittle, and the San Francisco 49ers seemingly fixed all their woes with a cross-country trip and a 34-3 drubbing of Jacksonville that ended a three-game skid.
Andy Reid again was a near-unanimous choice by The Associated Press for the top spot among NFL head coaches, receiving eight of nine first-place votes.