Scleroderma is an autoimmune, connective tissue disease that causes hardening and tightening of the skin and connective tissues. There are two classifications of Scleroderma, Localized Scleroderma and Systematic Scleroderma. It is estimated that 300,000 Americans suffer from Scleroderma, according to the Scleroderma Foundation. There are two different classifications for Scleroderma, Localized and Systematic. Localized Scleroderma usually affects the skin and rarely spreads elsewhere, while Systematic Scleroderma can affect other organs of the body besides the skin.