Way-too-early 2021 Detroit Lions game-by-game predictions: How many wins?The Detroit Lions will open the 2021 regular season at Ford Field against the San Francisco 49ers on Sept. 12, according to the newly released NFL schedule.
Detroit Lions 2021 regular season schedule released: View it hereThe Detroit Lions will open the 2021 regular season at Ford Field against the San Francisco 49ers on Sept. 12, according to the newly released NFL schedule.