Barkley, 49ers hit with potentially season-ending injuries
Start with running back, where Giants star Saquon Barkley is believed to have torn the ACL in his right knee early in their loss at Chicago. The 49ers' Jimmy Garoppolo tried to play through a right ankle injury before Nick Mullens took over for the second half. Tevin Coleman also left San Francisco's win over the Jets with a late knee injury. Along with Lock and Sutton, the Broncos lost defensive end Dre'Mont Jones to a knee injury in their defeat at Pittsburgh. Washington guard Brandon Scherff, who left early in Arizona with a knee injury, was among the offensive linemen hurt around the NFL on Sunday.
49ers blast Jets 31-13, but lose Garoppolo, Bosa, Mostert
It was a costly victory for San Francisco, which was already short-handed before losing Garoppolo to an ankle injury and Mostert to an injured knee. Defensive end Nick Bosa and defensive tackle Solomon Thomas were both carted off the field two plays apart with left knee injuries in the first quarter. Bosa was carted off the field with a left knee injury. Two plays later, Thomas needed to be carted off — also with a left knee injury —after an 8-yard reception by Chris Hogan. The drive was prolonged by a roughing-the-passer penalty on Henry Anderson when the Jets appeared to have stopped San Francisco on third-and-8.