The incident happened at 8:48 p.m. on Tuesday in the westbound lanes of I-94 near the Michigan MDOT Welcome Center in Port Huron Township.
No other vehicles were involved in the crash. Police said the Wales Township man was driving a 2010 Honda Civic and exited the expressway via the welcome center entrance.
Witnesses told police the vehicle drove over the entrance drive curb, continued into a marshy area, and crashed into a large steel barrier.
The man was the only person in the vehicle and he was pronounced dead at the scene. Police believe he had a medical episode, which caused the crash.
The investigation is ongoing.
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